Atenololi-Neo 25mg #20 Tab
Cardioselective beta 1 - blockers
Ingredients:
Active substance: Atenolol - 25 mg
Other ingredients: lactose, starch, sodium lauryl sulfate, magnesium pudzekarbonati, povidone, calcium or magnesium stearate, talc, aerosil.
Mode of action:
PD: hypotensive, Antianginalny, antiarrhythmics. Beta-adrenergic receptors primarily affects the heart, reduces the sympathetic innervation of the stimulating effects on the heart, the sinus node automaticity, heart rate, atrioventricular conduction slows down, decreases myocardial excitability, contractility of the heart's need for oxygen. The negative chronotropic effect is manifested within 1 hour after reaching 2 - 4 hours and the effect lasts for 24 hours antihepertenziuli. Nonselective beta-blockers compared with atenolol has less pronounced effect on the bronchi and peripheral arterial smooth muscle: slightly reduces vital function, virtually no weakening isoproterenol bronchodilators.
Systemic use of atenolol Neo,, '' leads to a gradual reduction in blood pressure. Stable hypotensive effect is achieved by treating the second weekend.
Pharmacokinetics of atenolol is absorbed from the gastrointestinal tract quickly, but incompletely - 50-60%. The maximum plasma concentration is reached within 2-4 hours after oral administration of the drug. Atenolol penetrates the blood-brain barrier poorly, cross the placental barrier, gets into breast milk. Practically not metabolized in the liver, the kidneys (85-100% as unchanged). H 1/2 is 6-7 hours.
Indications:
• hypertension;
• sinus tachycardia;
• arrythmia;
• atrial flutter and fibrillation;
• supraventricular and ventricular tahiarrhythmias prevention and treatment;
• functional genesis of cardiac hyperkinetic syndrome;
• myocardial infarction (stable hemodynamic time);
• angina attacks.
Contraindications:
• Hypersensitivity to any ingredient;
• II and III degree atrioventricular block;
• Sinus bradycardia;
• Chronic heart failure II and III of the stage;
• acute heart failure
• cardiogenic shock;
• hypotension;
• asthma;
• Children age.
Dosage:
Taken orally before meals, with a small amount of liquid. Dosage and duration of treatment is determined individually by your doctor. It is not permitted to change the arbitrary dosing and treatment. Discontinuation of the drug may lead to cardiac ischemia angina or myocardial infarction may contribute to the development or exacerbation of hypertension. Therefore, the drug should be removed step by step under the control of the doctor.
The initial dose is 25-50mg per day. If necessary, increase the dose to 50 mg after one week, and then, if necessary - 200 mg. The average daily dose - 100 mg per day. Further increase of the dose is not recommended, because the therapeutic effect is no longer growing, only increases the risk of side effects. To enhance the therapeutic effect of other antihypertensive drugs recommended list. ,, Atenolol Neo "maximum daily dose is 200 mg. Removing the need for a dose of the drug every 3-4 days for 3/4-cent cut.
Coronary artery disease: 50 mg 1 time a day.
Angina: The initial dose is 25-50mg per day. If a week is not received optimal therapeutic effect, increase the dose to 100 mg per day (one or two doses in the distribution). In some cases, the dose may be increased to 200 mg per day.
Hypertension: Treatment begins with 25-50mg-for-1 times a day. Stable hypotensive effect, need 1-2 weeks. In order to strengthen the effect of the dose can be increased to 100 mg per day. Further increase of the dose is not recommended, because the therapeutic effect is no longer growing.
Acute myocardial infarction stable hemodynamic parameters: orally administered 50 mg intravenous infusion within 10 minutes after, a second, 12 hours later, 50 mg taken. Subsequently, 6-9 days (blood pressure, ECG, blood glucose control) 50 mg or 100 mg 2 times a day 1 time a day.
Secondary prevention of myocardial infarction: 100 mg administered twice a day for 1 or 50 mg 2 times a day for 6-9 days in the hospital or to subscribe to.
Heart rhythm disorders takisistoluri: 50 mg 1 time a day.
Functional disorders of the cardiovascular system: 25 mg 1 time a day.
Elderly patients: from a single dose of 25 mg (dose can be increased under the control of blood pressure and heart rate).
Patients with renal excretory function is impaired, it is necessary to adjust the dosage depending on the creatinine clearance. 35 ml / min with high clearance is not a significant accumulation in the body of atenolol.
Table,, atenolol Neo "The maximum recommended dose in patients with renal insufficiency.
Table 1
Creatinine clearance
Ml / min / 1.73 m 2
The half-time, h
The maximum dose
15-35 16-27 50 mg per day
<15> 27 50 mg every other day
Hemodialysis patients atenolol Neo,, '' 50 mg / day immediately after dialysis. The drug is used in stationary conditions is necessary, because it can cause blood pressure to fall.
Side effects:
CNS: headache, dizziness, weakness, fatigue, insomnia.
Cardiovascular system: hypotension, bradycardia, cold feeling in extremities, heart failure.
Respiratory: bronchial obstruction syndrome.
Digestive system: nausea, diarrhea, constipation, dry mouth.
Endocrine: reduced potency, the development of hypoglycemia in patients with diabetes mellitus.
Allergic reactions: skin redness, itching.
Other manifestations: sweating, conjunctivitis, lacrimal fluid secretion reduction.
Special instructions:
The drug is prescribed with caution in patients with the following diseases: heart failure, respiratory chronic obstructive pulmonary diseases, diabetes (especially labile forms), Raynaud's disease, peripheral arterial obliterans disease, pheochromocytoma, thyrotoxicosis, in patients with renal excretory function failure, elderly patients.
Verapamilisa and simultaneous use of atenolol is not recommended, especially in patients with impaired conduction.
Klonidinisa and the simultaneous use of atenolol, the latter should be discontinued several days before clonidine discontinuation. Surgery is needed, a few days before surgery should stop,, atenolol Neo '' - to use a minimum of negative inotropic effect or be narcosis.
,, Atenolol Neo "use may reduce the tear fluid production, which should be considered in patients who use contact lenses.
Pregnancy and breast-feeding:
Atenolol placenta. The drug is used only in the case when the expected therapeutic effect for the mother outweighs the potential risk to the fetus.
Atenolol to mother's milk. Therefore, if necessary, to stop the use of the drug during lactation breastfeeding. If this is not possible, then the child is in need of qualified medical review.
Drug Interactions:
Insulin or oral hypoglycemic drugs, leads to the simultaneous strengthening of hypoglycemic effect, increase in blood pressure.
Diuretics, antihypertensive agents, concomitant use of nitrates getting stronger,, atenolol Neo "antihypertensive effect.
,, Atenolol Neo "simultaneously with reserpine, matildopas, clonidine, the alkuroniumis chloride may develop bradycardia, dry mouth.
Varapamil of diltiazem with atenolol simultaneously strengthened,, Neo "kardiodepresiuli action.
Concomitant use increases the risk of toxic effects of anesthetics.
Cardiac glycosides simultaneously strengthened bradycardia, atrioventricular conduction risks.
With estrogens reduces,, atenolol Neo "hypotensive effect, because the estrogens in the body fluid being detained.
Iodine-containing compounds in combination with the increased risk of anaphylactic reactions.
NSAIDs, especially indomethacin reduces,, atenolol Neo "antihypertensive effect.
Cigarette Smoking cessation can enhance,, atenolol Neo "therapeutic effect, as it increases metabolism and decreases in plasma concentration levels in the blood. It is necessary to adjust the dose.
Aminopilin with concomitant use of theophylline or caffeine increases the risk of development of hypotension and strengthening kardiodepresiuli action.
,, Atenolol Neo "and the combined use of clonidine Clonidine treatment discontinuation is necessary to extend a few more days.
Overdose:
Symptoms: bradycardia, dizziness, hypotension, cardiac arrhythmias, bronchospasm, cold limbs.
Treatment of severe bradycardia - atropine injection, severe hypotension during - dobutamine or dopamine input. Identified in accordance with the symptoms, as well as a cardiac glycoside or glucagon, selective beta-adrenomimetic means. It becomes necessary to train an artificial pacemaker installed.
Influence of vehicle and mechanisms management:,, atenolol Neo "is necessary to be careful while driving motor transport and mechanisms requiring concentration of attention and psychomotor speed of reaction, since it is possible to develop such reactions, which result in distractibility.
Packing:
The first 10 tablets in a blister on.
Secondary packing: 2 blisters in the box.
Storage: Store in a dry, protected from light and out of the reach of children, 15-25 ° C temperature conditions.
Expiry, or visual defects of the preparation can not be!
Pharmacy Issue: pharmaceutical product group II - a doctor's prescription.
Shelf life: 2 years.
