Aspirin (Acetylsalicylic acid) 0.5g №10 tab
Analgesic, antipyretic means
The basic physical and chemical properties: white, weak sour taste with a flat cylindrical shape nachdeviani tablets.
Ingredients: Each tablet contains 0.5 g of acetylsalicylic acid;
Other ingredients: potato starch, talc; Citric acid.
Dosage form:
Tablets.
Pharmacological group:
Analgesic, antipyretic means.
Mode of action:
The drug is characterized antipyretic, analgesic and anti-inflammatory action, also reduces platelet aggregation.
Main mechanism of action of acetylsalicylic acid inactivates the enzyme cyclooxygenase, resulting in the inhibition of prostaglandin, prostacyclin synthesis and tromboksinis. Prostaglandin production is reduced as a result of reducing the impact of their pyrogenic thermoregulatory center. In addition, the impact of reduced prostaglandin masensibilizebeli sensitive nerve endings, which reduces their sensitivity to pain mediatorebisadmi.
Trombosan А2- platelets in the synthesis of the drug leads to irreversible violation antiaggregatory action.
Pharmacokinetics:
Acetylsalicylic acid, after taking the drug, generating major metabolite - salicylic acid. Acetylsalicylic acid and salicylic acid absorption in digestive tract occurs rapidly and completely. The maximum level of the plasma concentrations reached in 10-20 minutes. The drug is excreted as metabolites, mainly kidneys. It penetrates the blood-brain barrier, also found in breast milk and synovial fluid.
Show:
• rheumatism, rheumatoid arthritis;
• infectious allergic myocarditis;
• temperature rise of infectious and inflammatory diseases;
• weak and medium intensity pain of various origins (including, neuralgia, myalgia, headache);
• thrombosis and embolism prophylaxis; Primary and secondary prevention of myocardial infarction; Cerebral blood flow in the ischemic type of violation of prophylaxis;
Contraindications:
• type of erosive and ulcerative lesions of the gastrointestinal tract in the acute phase;
• a history of aspirin or other nonsteroidal anti-inflammatory drugs, allergic reactions are brief;
• hemophilia;
• hemorrhagic diathesis;
• hypo-prothrombinemia;
• portal hypertension;
• K vitamin deficiency;
• liver and / or kidney failure;
• glucose-6-phosphate dehydrogenase deficiency;
• Reyes syndrome;
• Children under 3 years of age;
• I and III trimester of pregnancy, lactation,
Dosage:
The drug is taken orally, after meals, water, milk or mineral water.
Adults: a single dose of acetylsalicylic acid 50 mg to 1 g fluctuations; Daily dose - 3 g;
Children: A single dose of 3 years of age - 0,15 g; 4 year olds - 0.2 g; 5 years may receive 0.25 g; A single dose, if necessary, be allowed to receive 3 times daily for 4-8 hour intervals.
Brain circulatory disturbances, prevention and treatment of 0.125 g 0.3 g administered per day.
Unstable angina and myocardial infarction to prevent a repeat of the average daily dose of 0.125 g -0.325; Liver and kidney dysfunction in patients with dose reduction is necessary to increase the interval between doses or medication. The tablets may be getting ahead in water.
Side effects:
Digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea, rarely, erosive and ulcerative lesions develop, bleeding from the gastrointestinal tract, liver damage;
Central nervous system: long-term use can lead to dizziness, headache, blurred vision reversible disorders, tinnitus, aseptic meningitis;
Siskhltsarmomshobi system: rarely - thrombocytopenia, anemia;
Urinary system: rarely - renal dysfunction, long-term use - acute renal failure, nephrotic syndrome;
Allergic reactions: seldom - skin rash, angioedema, bronchospasm;
Drug Interactions: Concurrent use of anticoagulants, and increases the risk of bleeding. NSAID to enhance their therapeutic effect and side effects, respectively.
ASA treatment with methotrexate side effects from strength to strength;
Acetylsalicylic acid and oral antidiabetic drugs are receiving sulfonylureas group intensifies hypoglycemic effect of the latter.
If you are receiving corticosteroids increases the risk of bleeding in the gastrointestinal tract;
Acetylsalicylic acid reduces spironolaktonis, furosemide and the antihypertensive effect of promoting uric acid excretion from the body;
Overdose:
Mild poisoning may develop nausea, vomiting, epigastric pain in the district, as well as ringing in the ears, dizziness, blurred vision, hearing loss.
A significant degree of intoxication include thinking, confusion, drowsiness, collapse, trembling, shortness of breath, soul shekhutva, dehydration, hyperthermia, coma, alkaline reaction of urine, metabolic acidosis, carbohydrate metabolism.
ASA lethal dose for adults is 10 g, and the children - more than 3 g.
Treatment of acid-base balance and electrolyte balance are sodium bicarbonate, sodium citrate and sodium lactate solution Infusion body.
10 tablets in a blister.
Storage: Store at temperatures not exceeding 25ch the reach of children.
Visual defects of the preparation can not be!
Shelf life: 4 years.
Pharmacy Issue: III group (prescription)
