Pharmacological group:  Mucolytic action expectorant drug.
Drug form: Syrup.
Characteristics: Smell - a fragrant, taste - sweet, flavor - strawberries
International name: Bromhexinum. (N – (2-amino–3,5 dibromobenzene)–N- Methylcyclohexylamine hydrochloride).
Composition:
Active substance: Bromhexin hydrochloride – 4mg/5ml;
Aiding substances: Propyleneglycol, sodium benzoate, citric acid, sugar, strawberry flavor, distilled water.
Pharmacological operation:
Pharmacodynamics: Bromhexin reveals mucolytic (secretory) and expectorate action. Mucolytic effect is related to mucopolysaccharide fiber depolymerization and secretion mucus liquefaction.
Except that, Bromhexin stimulates endogenous surfactant output, that is necessary for alveols’ proper operation. Surfactant is a muco-polysaccharide nature surface-active substance, which is synthesized in alveols’ cells. Biosynthesis of surfactant is disordered at time of various diseases of bronchus and lungs. It causes alveols’ cells stability decrease and weakening.
Preparation has also weak anti-cough action.
Pharmacokinetics: After peroral intake Bromhexin is almost entirely absorbed in gastrointestinal tract and is excreted with urine basically unchanged form. Metabolizes in the liver, arises active metabolite – ambroxol, which has similar effect of Bromhexin on the organism. Bio-penetration of the preparation is about 80%. Maximal concentration in blood is reached in an hour. Half-value period makes up 4-5 hours. Bromhexin reaches in hematoencephalic and placental barrier, gets in the mother's milk.
Indication:
• Respiratory tracts and lungs’ diseases, followed by viscous sputum formation: acute and chronic bronchitis, bronchial asthma, pneumonia, laryngitis, pharyngitis, tracheitis, tracheobronchitis, pulmonary tuberculosis and etc.
• Productive cough treatment;
Order of intake and dosage: The drug is taken orally. 3 times a day,  independently of meal. Pay attention to intake sufficient amount of water, because increase of liquid supply helps therapy and desired swelling of secretion in bronchus.
Children from 2 to 6 years old: 2.5 to 5ml of syrup (2-4mg bromhexine hydrochloride) 3 times a day. Children from 6 to 14 years old and patients weighing less than 50 kg, 5-10ml syrup (4-8mg bromhexine hydrochloride) 3 times a day.
In adults over 14 year: 10-15ml syrup (8-12mg bromhexine hydrochloride) 3 times a day. Note: 5ml of syrup corresponds to one teaspoon.

Age of the patient A single dose (Teaspoon) A single dose (Mg) The daily dose (Teaspoon)
Children from 2 to 6 years old 0,5 – 1  2 - 4 1,5 – 3 (6 – 12мg)
Children from 6 to 14 years old 1 – 2 4 - 8 3 – 6 (12 – 24мg)
Over 14 years 2 - 3 8 - 12 6 – 9 (24 – 36мg)
As usual, the manifestation of the effect of the drug begins 24-48 hours after ingestion.  The duration of treatment - from 4 days to 4 weeks.
Treatment duration depends on progress of disease. Preparation shouldn’t be intake more than 4-5 days without doctor’s consultation. Course of treatment may be extended up to 4 weeks.
In case of liver and kidney functions disorder, dosage reduction is necessary.
In the case of dose omission, it should be taken according to primary scheme.
Contraindication:
Hypersensitivity toward components including in the preparation.
Side effects:
• From the side of digestion system: dyspepsia in the form of nausea  and vomiting, pain in epigastrium, also exacerbation of stomach and duodenum ulcer, bleeding from intestine;
• From the side of central system: dizziness, headache;
• Allergic reactions: itch, rash, nettle-rash, angionervous swollen.
Special indications:
Intake of ,,Bromhexin neo’’ isn’t recommended together with cough reflex blocking preparations that are used for dry cough treatment. Their simultaneous usage arise danger of secretion congestion in the respiratory tracts, which reinforces inflammatory process. Combined intake is possible only interchange of the following preparations: expectorant preparations (Lazolvan, Mucaltin) are intake during a day, but anti-cough preparations - once at bedtime.
Pregnancy and lactation period: Preparation may be used at time of pregnancy and lactation period, only with the consent of doctor, when expected benefit for mother exceeds potential risk of the fetus.
Influence on driving motor transport and mechanisms: Preparation intake doesn’t influence on vehicle and mechanism management.
Interaction with other preparations: The preparation may be prescribed in combination with bronchodilators and antibacterial preparations. It shouldn’t be intake together with cough depressant drugs (codeine include). It is possible to intake combined, in the day-time - expectorant and in the evening – alternately with anti-cough preparations (for perfect sleep).
Bromhexin neo is incompatible with alkaline solutions.
Overdose: In case of excessive doses side effects are not dangerous. In case of heavy cases there may be necessary blood flow control. Treatment is symptomatic.
Caution: The drug is prescribed with caution during pregnancy and lactation period, children’s age.
Package: 
Primary packing: 100 ml in polymeric material vial.
Secondary packing: The bottle is placed in a carton box with polyethylene measuring glass and instruction.
Validity: 2 years.
In case of visual defects and expiry of validity date, the preparation can not be used.
Storage conditions: Store on 15-25ºC temperature in a dark, dry place and keep away from children.
Issue: III group of a pharmaceutical product - issued without prescription.