Raunatine Neo №50 tablets
Pharmacotherapy group: Sympatholytics.
ATC
code: CO2AA.
International
name: Rauwolfia alkaloids.
Drug
form:
Coated tablets.
Composition:
Active
substance: Rauwolfia total alkaloids – 2mg.
Aiding
substances: magnesium carbonate, starch, lactose, talcum, calcium stearate, polyvinylpyrrolidone,
saccharose, aerosol, titanium dioxide, green color.
Pharmacological
operation:
Pharmacodynamics: Raunatin contains complex of Rauvolfia
alkaloids: reserpine, serpentine, ajmaline and
etc. Raunatin has hypotensive
action, which is conditioned by the reduction of biogenic monoamines
(noradrenaline, dopamine,
serotonin) concentration in the Central Nervous
System. By the violation of mediators’ deposition process in the presynaptic
terminals, the preparation blocks adrenergic transmission (innervation), which
causes gradual reduction of blood pressure. The peculiarity of the drug is increase of kidney’s glomerular
filtration and accordingly increases of blood supply.
Raunatin has also antiarrhythmic action, it restores excitation
and patency processes in the heart muscle. It has soothing
action on the Central Nervous System. Therapeutic effect
of the preparation reveals gradually. During 10-14 days from the beginning of
treatment and maintains during 2-3 months.
Pharmacokinetics: Alkaloids of the preparations are well absorbed from
the gastrointestinal
tract. Maximal concentration is achieved after 1-2 hours from intake. 40-50% of
the preparation relates to blood plasma proteins. Semiejection period makes up 50-170
hours. Metabolizes in the liver and spleen. Basically eliminated with
excrements and urine.
Indication: Light and
moderate hypertension.
Order
of use and dosage: Raunatin
is prescribed in adults and is taken orally after a meal. Initial dose of the first
day is 1 pill in a day, the second day – 1 pill 2 times in a day, the third day
– 1 pill 3 times in a day. Then the total dose is increased up to 4-6 pills in
a day. After a stable therapeutic effect preparation dose is gradually reduced
1-2 pills in a day.
Maximal daily dose is 6 pills. Treatment course makes up 3-4
weeks. However the preparation is often taken for a long time, the maintenance
dose 1 pill in a day. Daily dose and duration of treatment is decided by a
doctor.
Contraindication: Hypersensitivity
toward Rauvolfia
alkaloids, gastric and duodenal ulcer, arterial hypotensia, heart failure,
heart organic damages, bradycardia, expressed cerebral atherosclerosis,
depression, epilepsy, parkinsonism, bronchial asthma, pregnancy and lactation.
Side effects: When taking Raunatin according to recommended doses it doesn’t cause
side effects.
In some cases there may develop:
abdominal pain, nausea, rash on the skin, swelling of the mucous membrane,
increased sweating, dry mouth, depression, bradycardia. Remove of side effects
can be achieved by the reduction of dose or after a short break of preparation
intake (1-3 days). But in case of clear intolerance stop taking of drug.
Overdose:
When taking the preparation in high
doses it is possible to reinforce above stated side effects.
Symptoms: General weakness, expressed hypotensia,
sweating. In hard cases after a brief euphoria there develop, sleepiness,
depression, loss of consciousness.
Treatment: Stop taking of
preparation, gastric lavage, intake of activated charcoal, artificial diuresis,
in case of need intravenous introduction of Rheopolyglukin
or Mesaton by adding Аngiotensinamidum or 2% noradrenaline hydrotartrate.
Subcutaneously
injected also 10% caffeine- benzoate sodium solution.
Interaction with other medicines: Antihypertensive
operation of Raunatin reinforces at time of
using together with other hypertensive preparations.
The preparation is safely prescribed with quinidine, octadinum,
cardiac glycosides, because it may strengthen their toxic action. Hypotensive
effect of Raunatin becomes stronger by
its combination with diuretics. Raunatin reduces efficiency of Parkinson's
drugs.
Usage
during pregnancy and lactation period: Use of preparation in
pregnancy and lactation period isn’t recommended.
Influence on vehicle and mechanisms management: The preparation can
break the fast response, especially in the beginning of treatment. So, the
patient should avoid an activity, which needs increased attention and quick
psychomotor reaction.
Drug
release form: Primary package: N 10 pills on the blister.
Secondary package: 5 blisters
in the box with instruction.
Date of expire: 3 years.
Do not use preparation after
expire or in case of visual defect.
Storage
condition: Is kept in a dry and dark place
in condition of 15-250C temperature, and inaccessible for children.
Order
of issue from pharmacy: III group of pharmaceutical product, is issued without prescription.
Producer: “Neopharmi” LTD.
Davit Aghmashenebeli alley 12
km, Tbilisi, Georgia.
Tel/fax: + 995 (32) 259 64 46,
259 57 90
