Folic acid – 400mcg №60 tab
ATC Code: B03BB01.
Pharmacological group: Vitamin mean.
Drug form: Tablets.
Description: Light yellow
tablets. Dark insets in tablets are permitted.
Composition: One
tablet contains:
Folic
acid – 0.4 mg (400 mcg);
Aiding
substances: Lactose, polyvinylpyrrolidone, calcium stearate, starch, talc.
Pharmacological operation: Folic
acid belongs to B group vitamins. Folic acid is metabolized in organism to
tetrahydrofolic acid. It is a coenzyme, which is necessary for normal maturing
of megaloblast and production of normoblast. Folic acid stimulates
erythrogenesis.
It
participates in synthesis of amino acids, in an exchange process of nucleinic
acids, purine, pyrimidine and choline.
Pharmacokinetics: After
peroral application the preparation is absorbed from duodenum and proximal part of small intestines. 98,5 % from
the entered dose is defined in blood after 3-6 hours. Before absorption folic
acid is restored by means of enzyme (dehydropholatreductase).
Deposition and metabolism of folic acid is carried out in liver. 50 % of dose
is eliminated with urine.
Indication:
· Treatment
and prevention of anemia during pregnancy and
lactation period.
· Anaemia
developed through deficiency of folic acid.
Contra-indication: Additional
sensitivity towards folic acid,
deficiency of cobalamine, children age, Biermer-Ehrlich anemia.
Application ang and
dosage rule: Preparation is taken
perorally.
For
deficiency of folic acid - 400 mcg (1 tablet) a day.
For
prevention defect development of nervous stem while first term of pregnancy -
400-800 mcg (1-2 teblet) is prescribed.
Side effects: Allergic reactions: rash, itch, bronchospasm,
erythema, heat.
From the side of gastro-intestinal tract: nausea,
meteorism, bitter taste in mouth, anorexia.
Other: Long term usage of the preparation may cause
B12 hipovitaminosis.
Caution: Long term usage of the preparation may cause reduction
of cyanocobalamin concentration in blood. At time of Biermer-Ehrlich anemia for
the purpose of avoiding neurologic complications the combination of folic acid
and cyanocobalamin is expedient.
Pregnancy and lactation period: Application of the preparation is inevitable while
pregnancy preparation period (1-3
month earlier before planed pregnancy) and in first term of pregnancy.
Interaction with other medical means: In combination with
chloramphenicol, neomycin, tetracycline, absorption of folic acid decreases.
In combination of folic acid with phenytoin,
pyrimidine, sulfasalazine, chloramphenicol, hormonal contraceptives, their
therapeutic effect decreases.
Overdosage: Overdosage may be occurred in case long-term usage
of the preparation (more than 1-2 month) in doses more than 1000 mcg a day, or
while combination of the preparation with other vitamin-mineral complexes.
Order of issue: Pharmaceutical product group
III group - (prescribed without prescription).
Shelf life: 2 years.
Storage conditions: Store at 15-25ºC temperature, in a light protected
place, keep away from children.
It is forbidden to use the preparation after the term
expires or having defects after the visual inspection.
Package: Folic acid – 400 mcg;
Primary packing: № 20 tablets on blister;
Secondary packing: 3 blister in a cardboard box.
