Neosil (Nimesulide) №20 Tab
Non-steroidal anti-inflammatory agent
ATС Code: M01AX17.
Drug form: Pills.
Composition: Active substance: Nimesulide - 100 mg.
Aiding substances: starch, micromeritic cellulose,
sorbite, talc, calcium or magnesium stearate, polyvinylpyrrolidone.
Neosili is an anti inflammatory nonsteroidal mean form
the Sulfonanilid group. Is characterizes with anti inflammation, painkilling
and temperature lowering action, that is caused by selective competitive
inhibition of the enzyme cyclooxygenase – 2; it suppresses prostaglandins –
intumescence, inflammation and pain mediation synthesis. Besides that, the
preparation suppresses synthesis of cartilaginous tissue’s disbanding enzyme
(Colagenesis, Stromelizin, Elastaza), which delays cartilaginous tissue’s
damage and subserves regulation of this system.
After internal taking, Nimesulid is absorbed well from
intestine tract. Ingest of food reduces absorption speed, irreplaceable to
absorbing quality. Nimesulid’s maximal concentration in blood plasma is
achieved after 1,5 -2,5 hours taking, but its operation continues approximately 6 hours. 99% of Nimesulid
relates to plasma proteins, actively metabolizes in liver, 80 % of metabolite
is exiled by means of urine, but 20% - together with fecal mass.
· At time of joint and muscles diseases
(different genesis osteoarthritis, among them rheumatic gout, osteoarthrosis,
ankylosing spondylitis, bursitis, tendenitis);
· For pain alleviation at post operational
and posttraumatic period, at time of osteoarthritis, strain and dislocation
pains and for inflammation treatment (arthralgia, myalgia);
· At time of infectious - inflammatory
diseases in otolaryngology;
· At time of teeth and headache, also
dysmenorrheal (at time of painful menstruation);
· At time of fever current diseases (like
involving in combined therapy).
Contra-indication: High sensitivity towards the Nimesulide and other
components of the preparation; high sensitivity towards
acetylsalicylic acid or other anti-inflammatory nonsteroidalm means; stomach
and duodenum ulcerous diseases in an acute phase; normal
or expressed disorders of the liver or kidney function; pregnancy and lactation
period; for children – till 12 age;
rule and dosage: Neosili is taken perorally, after eating, drinking plenty of
It is commonly prescribed – 100mg (1
tablet) 2 times in a day. Given the state of the patient, and the effectiveness
of treatment dose can be increased to 200 mg two times a day.
In aged people choose and reduce of doses is
determined by the doctor according to the patient’s condition.
For children up to 12 year Neosili is only prescribed
by the doctor’s recommendation.
Taking the drug recommended as possible in
a short time, for whatever cvesti minimize the risk of side effects (for not
more than 15 days).
Side effects: Neosili is characterized with
good endurance, although there may be developed:
From the side of
gastrointestinal tract: discomfort of epigastrium, nausea and diarrhea;
From the side of central
nervous system: headache, insomnia, nausia.
Alergic reactions: rash on the skin, erythema, hives,
Rarely there may be
developed oliguria with liquid retain
and local or diffuse intumescence of the tissue.
Like other anti-inflammatory
nonsteroidal means Neosili may cause Steven
Johnson’s, Layel’s syndrome, also anaphylactic reactions.
In case of side-effects occurance
shoul get consultation from doctor and stop taking the preparation.
Safety measures: Neosili if safely prescribed for those
patients who have blood coagulation system disorder and intestine system
diseases, also patients who take anticoagulants or antiaggregant. Patients who
have kidney’s functional disorder have to reduce dosage of Nimesulide with
consideration of hanking filtration indicator.
The preparation may cause liquid retain in the
tissues, so, Nimesulide should be given safely to those patients who have heart
safely given to aged patients, especially when there is expressed age weakness.
It is necessary to be safely at time of prescribing
Neosil and anticoagulants, diuresis means, antihypertensive preparations,
hypoglycemic preparations, digoxin, phenytoin, lithium preparations and other
nonsteroidal anti-inflammatory means, cyclosporine and methotrexate
Overdose: In case of overdosage
following symptoms may be occurred: nausea, vomiting, insomnia. Treatment is
symptomatic, stomach ablution and taking
of activated carbon is recommended.
lactation period: Usage of Neosili is not
recommended during the period of pregnancy and lactation.
Influence on ability of
management of motor transport and mechanisms: Caution should be taken
because the preparation may cause sleepness and dizziness.
with other drugs: Caution should be exercised with concomitant
administration of Neosili and anticoagulants, diuretics, antihypertensive
drugs, hypoglycemic drugs, digoxin, phenytoin, lithium, other non-steroidal
anti-inflammatory drugs, cyclosporine, methotrexate, as there may be the case
packing: № 10 tablets in polyvinylchloride blister. Secondary packing:
2 blisters are located in a cardboard box.
on 15-25ºC temperature in a dark, dry place and keep away from children.
Validity: 2 years.
II group of a pharmaceutical product, issued with prescription