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Aloferi #20 cap
 Antanemic drug

Drug form: capsules.

Composition:

Active substances: Ferric (II) sulphate - with 50.0 mg iron containment, Dry extract of aloe -50.0 mg,  Ascorbic acid - 50.0 mg, Folic acid - 1.0 mg.

Aid substance: Aerosil.                                                        

Dry extract of aloe contains complex of biologically active substances: derivative anthracene (an aloe-emodin, aloin, aloinozide), bitter glycoside, vitamins, enzymes, organic acids, polysaccharide.

Pharmacological operation:

Ferric (II) sulphate:

·         Iron is a structural element of hema;

·         It is necessary for haemoglobin synthesis;

·         Is a part of myoglobin and some enzymes;

·         It is deposited in organism.

Ascorbic acid:

·         Causes restoration of trivalent iron in to bivalent ionic iron;

·         Improves absorption of iron from food;

·         Regulates passableness of capillaries;

·         Provides collagen and procollagen synthesis;

·         Plays a considerable role in the course of oxidation – restoration;

Folic acid:

·         It is necessary for normal maturing megaloblast and formation of normoblast, stimulates erythrogenesis;

·         Participates in synthesis of amino acids, in exchange of nuclein acids, purine, pyrimidine, chlorine;

·         During pregnancy protects organism from teratogenic process.

Dry extract of aloe: 

·         Has bactericidal, anti-virus, anti-inflammatory action;

·         Contains biogenetic stimulators;

·         Strengthens organism resist ability towards  infectious diseases;

·         Strengthens reclaiming processes of  skin and mucous membrane;

Indication:

·         Hypochromic anemia (iron-deficient) of different aetiology;

·         The increased requirement on iron (pre - and puberty age, the lactation period);

·         Alimentary deficiency of iron and vitamins.

Contra-indication:

·         Anemia of different aetiology;

·         Hemosiderosis, hemochromatosis;

·         Crone disease, ulcer enterocolitis;

·         The Cirrhosis, a chronic pancreatitis;

·         Diffuse glomerulonephritis;

Side effects:  

Anorexia, nausea, diarrhea, tachycardia, rash on the skin. It is necessary to supervise function of kidneys and arterial pressure.

Administration and and dosage rule: Administreted perorally.

for adults : 1 – 2 capsules 3 times a day after meal.

For children 4 – 7 year old: 1 capsule 2 times in a day after meal;

For children 7 – 14 year old: 1 capsule 3 times in a day after meal;

For children 14 – 16 year old: 1 capsule 4 times in a day after meal.

Duration of treatment course 8 – 12  weeks.

Dosage omission: In case of dosage omission is not permitted taking double dose. Next dose should be taken according to the previous schedule.

Pregnancy and lactation period: During the pregnancy and lactation period the preparation is prescribed when iron deficiency is ascertained in organism.  

Interaction with other medical preparations: While taking the preparation with thiazides, liqourices’s preparations and  corticosteroids the risk of potassium deficiency occurrence is increased.

Because of the fact, that iron absorbtion process is slowed, it’s not recommended to take the preparation with antibiotics, penicillamine, antacids.

Influence on ability of management of motor transport and mechanisms: The preparation does not influence on ability of driving and working with techniques. 

Caution: Long-term usage of the preparation may cause potassium deficit in organism and enhance action of cardiac glycosides, anti antiarrhythmic drugs.

Overdosage: Simptoms of overdosage are:weakness, fatigue, paresthesia, colorless, low preasure, pain in epigastrium, dizziness, diarrhea with blood admixture, vomiting, cianosis.

Treatment: gastric lavage, taking milk, raw egg. For specific treatment deferoxsamine is prescribed preoprally and parenterally.  For acute poisoning, when iron is not still absorbed, 5-10 g deferoxsamine is prescribed (10-20 ampoule is diluted in water). For absorbed iron deferoxsamine is prescribed parenterally. For Children – 15 mg/hour, adult -5 mg/hour (till 80 mg/kg in a day).  For light poisoning – for children 1g in 4-6 hour, for adult 50mg/kg (till 4-g in a day).   

Package: 

Primary packing: 10 capsules in polyvinylchloride blister.

Secondary packing: 2 blisters are located in a cardboard box.

Issue: III group of a pharmaceutical product - issued without prescription.

Storage conditions: stored at 18-25ºC temperature in a dark, dry place and keep away from children.

Shelf-life: 2 years.



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