Cinnarizin Neo 25mg #40 Tab
Calcium channel blocker
Generic name: Cinnarizine
ATС Code: N07CA02
Drug form: Tablets.
Pharmacological group: 4th generation Calcium channel blocker;
Composition:
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Active substance:
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Cinnarizine – 25
mg.
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|
Aiding substances:
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Lactose monohydrate, starch,
talcum, calcium or magnesium
stearate, povidone.
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Pharmacological operation:
Pharmacodynamics: Cinnarezine
mechanism of action is related to Calcium channel blocker, which holds
up availability and storage of Calcium ion
in blood-vessel smooth muscles cells. It causes blood-vessels widening, improves
brain, coronary and peripheral blood circulation. At the same time, Cinnarezine reduces neurotransmitter:
noradrenaline, vasopressin and serotonin vasoconstriction action, improves blood rheological
characteristic, increases erythrocyte membrane elasticity, that promotes
reduction of blood viscosity and microcirculation improve.
Cinnarezine
facilitates
vestibular apparatus centers excitability decrease, doesn’t affect on cardiac muscle compression frequency and arterial pressure.
Links to antihistamine receptors, therefore reveals insignificant antihistamine
effect.
Pharmacokinetics: After peroral intake the preparation is quickly
and well absorbed from the gastrointestinal tract.
Cmax is reached in 1-3 hours. Semiejection period makes up 4 hours, 80% relates to proteins, intensively metabolizes mainly in
N- dialkylation way, 1/3
metabolite is excreted by kidneys,
2/3 – by intestines.
Indication:
·
Blood circulation
disturbance in brain;
·
Peripheral blood
circulation disorder;
·
Symptomatic
treatment of vestibular apparatus diseases and Meniere’s syndrome, which is
expressed by dizziness, nausea, vomiting, tinnitus;
·
Migraine attack prevention;
·
Kynesis (road disease) prevention and treatment.
Contraindications: Hypersensitivity toward compound components or acting substances; pregnancy and lactation period.
Order of intake and dosage: Is taken peroraly at time of eating or after
eating. Dosage regime is established by the doctor individually. Maximal around-the-clock dose for adults makes up 225mg. (9
pills).
At time of blood circulation
disturbance in brain: In
adults and children over the 12 years: is prescribed 25mg. (1 pill) 3 time in a
day. Children 8-12 age: is
prescribed half dose of adults 3 times in a day. Children 5-7 age: is prescribed quarter dose of adults 3 times in
a day.
At time of peripheral blood
circulation disorder: For adults is prescribed 50-75mg. (2-3 pills) 3
times in a day.
At time of vestibular disturbances,
Meniere’s syndrome, Kynesis (road
disease): In adults and
children over the 12 years: 1 pill - half hour before the trip and 1 pill
during travel in each 6 hours. Children 8-12 age: half dose of adults’ is
recommended half hour before trip. Children 5-7 age: quarter dose of adults’ is
recommended half hour before trip.
Recommended overdose is forbidden. Intake of “Cinnarezine Neo” is necessary during several months, in order to
reach the best therapeutic effect. Treatment
should be started by the low dose (half of the recommended dose), and then
daily dose should be increased gradually until the desired therapeutic effect.
Side effects: Rarely may develop the following
side effects: sleepiness, feeling
of fatigue, weakness, headache, dry mouth, dyspepsia events, allergic
reactions, sweating. Great dose intake for a long time in elderly may reveal
extrapyramidal disorder symptoms (tremor, balance disorder) which require
preparation remove.
Special instructions: The preparation is prescribed carefully:
- Patients who
has parkinsonism disease or patients having extrapyramidal disorder
symptoms (trembling, orientation and balance disorder);
- Drivers and
patients whose
activity needs attention concentration and quick psychomotor reaction.
- At
time of arterial hypotension (round-the-clock dose of Cinnarezine must be
reduced up to 50mg.)
- At
time of long use, it is recommended to check liver and kidney function,
also blood.
Pregnancy and
lactation: Usage of
preparation at time of pregnancy and lactation isn’t recommended, as there
isn’t clinical research data concerning its safety.
Interaction with
other medicines or other sort
interaction: Simultaneous
reception of Cinnarezine and alcohol, tricyclic
antidepressants, central nervous system suppressing action preparations causes
their effects potentiation. Cinnarezine
reinforces nootropic, hypotensive and blood vessel widening preparations operation. Antihistaminic effect of the
preparation may cause false negative result at time of allergin sampling, so it
is recommended to terminate preparation reception 4 hours prior to allergic
sampling. Cinnarezine may cause false positive reaction in sportsmen at time of
anti-doping test.
Overdose:
Symptoms: sleepiness, muscle weakness, tremor, vomiting.
Treatment: treatment is symptomatic, gastric lavage is
necessary; there is prescribed activated charcoal or other adsorbent. Specific
antidote doesn’t exist.
Influence of vehicle and mechanisms management: Preparation may cause sleepiness. Patients whose activity needs attention concentration and quick psychomotor action should be careful.
Package: 20 tablets on polyvinyl chloride blister, 2 blisters in the box.
Storage conditions: Store on 15-25ºC temperature in a dark, dry
place and keep away from children.
In case of visual defects and expiry
of validity date, the preparation can not be used.
Order
of issue: Pharmaceutical
product group II - issued with a doctor's prescription.
Validity: 3 years.
