Ciprofloxacin 500 mg # 20 tabletts
Description: white colour tablets with a cutting.
Composition:
Hydrochloride of Ciprofloxacinum 0.500 g.
Aiding substances: Starch, lactose, talcum, calcium stearate or magnesium, polyvinylpyrrolidone.
Pharmacological operation:
Wide range operating antimicrobial preparation from fluoroquinolones group. It has bacteriocid operation: causes DNA gyrase inhibition of bacteria enzyme, by that reason replication of DNA and synthesis of bacteria cells' disorder. Ciprofloxacin operates on microorganisms as in propagation as well as, rest phase.
The preparation is active toward gram-positive and gram-negative microorganisms: Escherichia coli, Salmonella spp, Shigella spp, Citrobacter spp, Clebsiella spp, Enterobacter spp, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Campylobacter jejuni, Neisseria spp.; Toward intercellular microorganisms: Legionella pneumophila, Brucella spp., Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium-intracellulare; Toward gram-positive microorganisms: Streptococcus spp, Staphylococcus spp;
Majority of staphylococcus which are stable toward methicillin, is also stable toward Ciprofloxacin.
At time of taking Ciprofloxacin there doesn't develop cross resistance toward other antibiotics, which don't belong to other gyrase inhibition group, which makes it highly-effective toward stable bacteria of aminoglycoside, penicillin, cephalosporin and tetracycline.
Pharmacokinetics:
At time of peroral taking it is quickly absorbed from gastrointestinal tract. Food taking slows absorbtion, but doesn't make influence on Cmax and bio-access. Bio-access wavering from 50% to 85%. Maximal concentration of the preparation in blood is reached after 1-1,5 hours from taking;
Ciprofloxacin is well distributed in the tissues and liquids of the body; It reaches in gallbladder, lungs, kidneys, liver and uterine with high concentration. Ciprofloxacin accesses in bones, muscles, lymph, saliva and placental barrier.
It has bio-transformation in the liver (15-30%) by generation of less active metabolite. It is secreted by urine (50-70%); T1/2 makes up 3,5 hours.
Indication:
Infective-inflammatory diseases, which are caused by sensitive microorganism toward the preparation, among them:
- Infections of respiratory tract (except pneumococcal pneumonia);
- Infections of gastrointestinal tract (among them oral cavity, teeth), gallbladder and bile-expelling ways;
- Skin, mucous integument and soft tissues' infections (except methicillin-resistance golden staphylococcic infections);
- Musculoskeletal system apparatus infections;
- Kidneys' and urinogenital system infections;
- Genital organs' infections (gonorrhea, prostate gland, adnexitis, post delivery infections);
- Sepsis;
- peritonitis;
Contra-indications:
Pregnancy, lactation, children's and teenage age till 18 years, additional sensitivity toward Ciprofloxacinum.
Side-effects:
Nausea, vomiting, diarrhea, belly-aches, headache, dizziness, feeling of tiredness, dream infringement, dreadful dreams, hallucinations, sight infringement, crystalury, glomerulonephritis, dysuria, polyuria, albuminuria, hematuria, eosinophilia, leukopenia, hypogranulocytosis, number change platelet, tachycardia, infringement of heart rhythm, arterial hypotension, allergic reactions: Rash on the skin, nettle-rash, angioneurotic, Stevens-Johnson syndrome.
Caurion:
Preparation is safely prescribed for epilepsy, cerebral atherosclerosis diseased, because Ciprofloxacin may cause excitation impact of the central nervous system;
At time of preparation taking the sick should drink great amount of water to avoid crystaluria.
Order of taking and dosage: It is taking peroral.
At time of urinary tracts infections without complications: 250 mg 2 times in 24 hours for three days.
At time of urinary tracts infections without complications: 500 mg 2 times in 24 hours for 14 days.
Respiratory system, intestine tract infections: 250-500 mg 2 times in 24 hours;
In case of heavy infections (pneumonia, osteomyelitis) -750 mg 2 times in 24 hours;
At time of bone-joints system infections -500-750 mg, in case of gynecological infections 500mg 2 times in 24 hours;
For treating gonorrhea it is prescribed single with dose 250-500mg;
In case of very heavy infections dosage may be increased up to 750 mg 3 times in a day;
Treating course makes up from 5-14 days to 4-6 weeks.
Interaction with other preparations:
Using of nonsteroid antiinflamatory means together with Ciprofloxacinum increases risk of convulsions; antacid reduce its absorption, at reception with antiarrhythmic preparations raises PQ interval, the effect of peroral anticoagulants amplifies; amplifies effect of peroral antidiabetic means; zinc and calcium salts lower absorption Ciprofloxacinum; together with theofilin the risk of convulsion increases; sucralfate and iron reduce its absorption.
Overdose:
Overdose symptoms are insignificant. The symptoms developed as a result of reception of 12 gram: dizziness, shiver, headache, feeling of tiredness, convulsion, hallucination, turbidity of mind, the complaint of gastroenteric tract, liver and kidneys functions disorder, small crystals excretion and blood, in urine (crystaluria, hematuria).
In case of overdose gastric lavage is necessary after that activated coal is recommended. The special antidote does not exist. Only 10 % of a preparation can be allocated by means of hemodialysis and peritoneal dialysis.
In case of overdose immediately address to the doctor.
Pregnancy and lactation:
Is counter-indicative at time of pregnancy and lactation.
Influence on driving cars and other techniques:
Even reception of corresponding doses of Ciprofloxacinum can affect ability of reaction, and also driving of car and other mechanisms. It especially concerns initial stage of treatment, addition of dose, change of medicine and preparation reception with alcohol.
Package:
Primary packing: № 10 tablets in polyvinylchloride blister.
Secondary packing: 2 blister are located in a cardboard box.
Storage conditions: store in a dry and cool place.
In case of the expiry of the term of the validity or detection of defects at visual survey preparation use is not supposed.
Validity: 3 years.
Issue: pharmaceutical product group II - issued a doctor's prescription.
